based on well-defined nanoparticles
Nanomaterials are used more and more in everyday products. Understanding the impact of engineered nanomaterials on living systems is crucial for regulation and risk assesment. Besides making sure engineered nanomaterials do not have a negative effect on their environment, a growing understanding of nanoparticles also provides us the opportunity to (re-)assess the toxicity of airborne nanoparticles in for example diesel exhausts or workplaces that deal with processing metals.
It is known that reactive properties of nanomaterials, which are beneficial in for example catalysis, exhibit toxic affects in biological systems. Bulk gold is very inert, however, under 10 nm gold nanoparticles become toxic. Quantification of these toxic effects remains challenging, because of lack of reproducibility in toxicological testing.
Effects of car exhausts
Toxicity research on finedust and metallic particles from car exhausts
With the VSP-G1, carbon and other metallic materials are tested in combination with air to mimic car exhausts and test their toxicity.
Being able to produce well-defined nanoparticles and test them without the interaction of surfactants provides an opportunity to characterise the safety properties of particles based on reproducible data. With the VSP-G1 Metal Aerosol Source a stable and clean flow of well-defined pure metallic nano-aerosol can be generated, providing the ideal basis for nanotox research.
The VSP-G1 gives researchers access to easy production of metallic nanoparticles, metal oxide nanoparticles, carbon nanomaterial and radioactive nanomaterial. All these particles can be easily coupled to in-vitro and in-vivo systems.
Although nanoparticles are already being used in biosensors and enable novel treatments like brachytherapy and hyperthermia, they haven’t yet been used to their full potential. To pitch the possibilities of nanoparticles..